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在小鼠基因组信息学(MGI)资源中搜索有关小鼠生物学从基因型到表型的信息。

Searching the Mouse Genome Informatics (MGI) resources for information on mouse biology from genotype to phenotype.

作者信息

Shaw David R

机构信息

MGI User Support, The Jackson Laboratory, Bar Harbor, Maine.

出版信息

Curr Protoc Bioinformatics. 2009 Mar;Chapter 1:1.7.1-1.7.14. doi: 10.1002/0471250953.bi0107s25.

Abstract

The Mouse Genome Informatics (MGI) resource provides the research community with access to information on the genetics, genomics, and biology of the laboratory mouse. Core data in MGI include gene characterization and function, phenotype and disease model descriptions, DNA and protein sequence data, gene expression data, mammalian orthologies, SNPs and PCR polymorphisms, mapping data, and links to other bioinformatics databases. Data integration is supported through the use of standardized nomenclature, and through the use of controlled vocabularies such as the mouse Anatomical Dictionary, the Mammalian Phenotype Ontology, and the Gene Ontologies. MGI extracts and organizes data from primary literature. MGI data are shared with and widely displayed from other bioinformatics resources. The database is updated nightly with curated annotations, and regularly adds new datasets. This unit provides a guide to using the MGI bioinformatics resource.

摘要

小鼠基因组信息学(MGI)资源为研究界提供了获取有关实验室小鼠遗传学、基因组学和生物学信息的途径。MGI的核心数据包括基因特征与功能、表型和疾病模型描述、DNA和蛋白质序列数据、基因表达数据、哺乳动物直系同源基因、单核苷酸多态性(SNP)和聚合酶链反应(PCR)多态性、图谱数据以及与其他生物信息学数据库的链接。通过使用标准化命名法以及诸如小鼠解剖学词典、哺乳动物表型本体论和基因本体论等受控词汇表来支持数据整合。MGI从原始文献中提取并整理数据。MGI数据与其他生物信息学资源共享并广泛展示。该数据库每晚都会用经过整理的注释进行更新,并定期添加新的数据集。本单元提供了使用MGI生物信息学资源的指南。

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