Eppig Janan T
Jackson Laboratory, Bar Harbor, Maine.
ILAR J. 2017 Jul 1;58(1):17-41. doi: 10.1093/ilar/ilx013.
The Mouse Genome Informatics (MGI) Resource supports basic, translational, and computational research by providing high-quality, integrated data on the genetics, genomics, and biology of the laboratory mouse. MGI serves a strategic role for the scientific community in facilitating biomedical, experimental, and computational studies investigating the genetics and processes of diseases and enabling the development and testing of new disease models and therapeutic interventions. This review describes the nexus of the body of growing genetic and biological data and the advances in computer technology in the late 1980s, including the World Wide Web, that together launched the beginnings of MGI. MGI develops and maintains a gold-standard resource that reflects the current state of knowledge, provides semantic and contextual data integration that fosters hypothesis testing, continually develops new and improved tools for searching and analysis, and partners with the scientific community to assure research data needs are met. Here we describe one slice of MGI relating to the development of community-wide large-scale mutagenesis and phenotyping projects and introduce ways to access and use these MGI data. References and links to additional MGI aspects are provided.
小鼠基因组信息学(MGI)资源通过提供关于实验室小鼠遗传学、基因组学和生物学的高质量综合数据,支持基础研究、转化研究和计算研究。MGI在促进生物医学、实验和计算研究方面发挥着战略作用,这些研究旨在探究疾病的遗传学和发病过程,并推动新疾病模型的开发和测试以及治疗干预措施的验证。本综述描述了20世纪80年代末不断增长的遗传和生物学数据与计算机技术进步(包括万维网)之间的联系,正是这些共同开启了MGI的发展历程。MGI开发并维护了一个黄金标准资源库,该资源库反映了当前的知识状态,提供语义和上下文数据整合以促进假设检验,不断开发新的和改进的搜索与分析工具,并与科学界合作以确保研究数据需求得到满足。在此,我们描述MGI中与全社区大规模诱变和表型分析项目发展相关的一部分内容,并介绍访问和使用这些MGI数据的方法。同时提供了与MGI其他方面相关的参考文献和链接。