Bradley J G, Kallail K J, Dorsch J N, Fox J
Department of Family and Community Medicine, University of Kansas School of Medicine-Wichita.
J Am Board Fam Pract. 1991 Jul-Aug;4(4):201-6.
Pseudoephedrine is frequently used as a decongestant. Because of concern about the safety of pseudoephedrine in hypertensive patients, a clinical trial was conducted to determine whether blood pressure control was actually affected by this drug in a selected group of patients with hypertension. Twenty-nine patients with controlled, uncomplicated hypertension, who received drug therapy and ranged in age from 25 to 50 years, were randomized to a treatment or a control group. Subjects took either 60 mg of pseudoephedrine or placebo capsules four times a day for 3 days. From 0800 hours until 2200 hours each day, the subjects obtained hourly blood pressure measurements using a portable sphygmomanometer. An analysis of variance with repeated measures was calculated to determine group differences for systolic and diastolic readings. No statistically or clinically significant differences were found. Therapeutic doses of pseudoephedrine did not adversely affect control of hypertension in these selected patients.
伪麻黄碱常被用作减充血剂。由于担心伪麻黄碱在高血压患者中的安全性，开展了一项临床试验，以确定在一组选定的高血压患者中，这种药物是否真的会影响血压控制。29名年龄在25至50岁之间、接受药物治疗且高血压病情得到控制且无并发症的患者被随机分为治疗组或对照组。受试者每天服用4次60毫克伪麻黄碱胶囊或安慰剂胶囊，持续3天。每天从08:00至22:00，受试者使用便携式血压计每小时测量一次血压。计算重复测量方差分析以确定收缩压和舒张压读数的组间差异。未发现统计学或临床显著差异。在这些选定的患者中，治疗剂量的伪麻黄碱对高血压控制没有不利影响。
