用于研究白血病干细胞的人源化模型。
Humanized model to study leukemic stem cells.
作者信息
Bonnet Dominique
机构信息
Cancer Research UK, London Research Institute, Haematopoietic Stem Cell Laboratory, 44 Lincoln's Inn Fields, WC2A 3PX, London, UK.
出版信息
Methods Mol Biol. 2009;538:247-62. doi: 10.1007/978-1-59745-418-6_12.
The xenotransplantation model has been instrumental for the identification and characterization of human leukemic stem cells. In this chapter we will discuss the development of the immunodeficient model in the understanding of leukemogenesis, describe the different models of immunodeficiency now available and their values, as well as describe the methods used for the purification of LSCs. We will concentrate on the model of acute myeloid leukemia, as it was the first type of leukemia for which the xenotransplantation model was developed.
异种移植模型对于人类白血病干细胞的鉴定和特征描述具有重要作用。在本章中，我们将讨论免疫缺陷模型在白血病发生机制理解方面的发展，描述目前可用的不同免疫缺陷模型及其价值，以及描述用于纯化白血病干细胞的方法。我们将重点关注急性髓系白血病模型，因为它是首个开发出异种移植模型的白血病类型。
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