通过异种移植模型对白血病干细胞进行体内评估。
In vivo evaluation of leukemic stem cells through the xenotransplantation model.
作者信息
Bonnet Dominique
机构信息
Cancer Research UK, London Research Institute, Haematopoietic Stem Cell Laboratory, London, United Kingdom.
出版信息
Curr Protoc Stem Cell Biol. 2008 Dec;Chapter 3:Unit 3.2. doi: 10.1002/9780470151808.sc0302s7.
The xenotransplantation model has been instrumental for the identification and characterization of human leukemic stem cells. This unit describes our current method for the engraftment of human leukemic patients' samples in the xenotransplanted mouse model. We concentrate uniquely on the model of acute myeloid leukemia, as it was the first type of leukemia for which the xenotransplantation model was developed. Nevertheless, the Basic Protocol could be applied to other sorts of blood disorders.
异种移植模型对于人类白血病干细胞的识别和表征具有重要作用。本单元描述了我们目前在异种移植小鼠模型中植入人类白血病患者样本的方法。我们仅专注于急性髓系白血病模型，因为它是首个开发出异种移植模型的白血病类型。然而，基本方案也可应用于其他类型的血液疾病。
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