Shinjo Takuya, Kagami Ryogo
Palliative Care Unit, Shakaihoken Kobe Central Hospital, 2-1-1 Souyama-cho, Kita-ku, Kobe, Hyogo 651-1145, Japan.
Support Care Cancer. 2009 Jun;17(6):753-5. doi: 10.1007/s00520-009-0608-4. Epub 2009 Mar 11.
Malignant bowel obstruction (MBO) is a complication in advanced cancer patients with abdominal and pelvic malignancy. Recent research has established the efficacy of octreotide for MBO-related symptom relief. The mechanism that octreotide increases water absorption in case of MBO has not been demonstrated except for experimental animal and normal human model.
We present a 60-year-old man with pancreatic cancer and MBO treated with octreotide. Radiological imaging showed the disappearance of large-volume fluid retention in the small intestine with alleviating vomiting within 2 days. This radiological change might result from the effect of octreotide increasing water absorption in intestine tract.
恶性肠梗阻(MBO)是晚期腹部和盆腔恶性肿瘤患者的一种并发症。最近的研究已证实奥曲肽对缓解MBO相关症状有效。除了实验动物和正常人体模型外,奥曲肽在MBO情况下增加水吸收的机制尚未得到证实。
我们报告一名60岁胰腺癌合并MBO患者接受奥曲肽治疗的病例。影像学检查显示,小肠内大量液体潴留消失,呕吐在2天内得到缓解。这种影像学变化可能是奥曲肽增加肠道水吸收的作用所致。