Wnt 信号通路在肺发生中的作用。
Wnt signaling in lung organogenesis.
机构信息
Department of Pediatrics; National Jewish Medical Research Center; Denver, Colorado USA.
出版信息
Organogenesis. 2008 Apr;4(2):100-8. doi: 10.4161/org.4.2.5856.
Abstract
Reporter transgene, knockout, and misexpression studies support the notion that Wnt/beta-catenin signaling regulates aspects of branching morphogenesis, regional specialization of the epithelium and mesenchyme, and establishment of progenitor cell pools. As demonstrated for other foregut endoderm-derived organs, beta-catenin and the Wnt/beta-catenin signaling pathway contribute to control of cellular proliferation, differentiation and migration. However, the contribution of Wnt/beta-catenin signaling to these processes is shaped by other signals impinging on target tissues. In this review, we will concentrate on roles for Wnt/beta-catenin in respiratory system development, including segregation of the conducting airway and alveolar compartments, specialization of the mesenchyme, and establishment of tracheal asymmetries and tracheal glands.
摘要
报告基因、基因敲除和基因过表达研究支持这样一种观点，即 Wnt/β-连环蛋白信号通路调节分支形态发生、上皮和间充质的区域特化以及祖细胞库的建立等方面。正如其他前肠内胚层衍生器官所证明的那样，β-连环蛋白和 Wnt/β-连环蛋白信号通路有助于控制细胞增殖、分化和迁移。然而，Wnt/β-连环蛋白信号对这些过程的贡献受到作用于靶组织的其他信号的影响。在这篇综述中，我们将集中讨论 Wnt/β-连环蛋白在呼吸系统发育中的作用，包括气道和肺泡隔的分离、间充质的特化以及气管不对称性和气管腺的建立。
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