一种来自面包树的氧杂环庚三烯黄酮，对P-388细胞具有细胞毒性活性。

An oxepinoflavone from Artocarpus elasticus with cytotoxic activity against P-388 cells.

作者信息

Musthapa Iqbal, Juliawaty Lia D, Syah Yana M, Hakim Euis H, Latip Jalifah, Ghisalberti Emilio L

机构信息

Institut Teknologi Bandung, Natural Products Research Group, Faculty of Mathematics and Natural Sciences, Jalan Ganesha 10, Bandung 40132, Indonesia.

出版信息

Arch Pharm Res. 2009 Feb;32(2):191-4. doi: 10.1007/s12272-009-1134-0. Epub 2009 Mar 13.

DOI:10.1007/s12272-009-1134-0

PMID:19280147

Abstract

A new oxepinoflavone, artoindonesianin E1 (1), was isolated from the wood of Artocarpus elasticus, along with four known prenylated flavones: artocarpin (2), cycloartocarpin (3), cudraflavones A (4) and C (5). The structure of the new compound was identified by spectroscopic methods. Upon cytotoxic evaluation against murine leukemia P-388 cells, the new compound showed IC(50) 5.0 microg/mL.

摘要

从面包树的木材中分离出一种新的氧杂环黄酮，即面包果黄酮E1（1），以及四种已知的异戊烯基黄酮：面包果素（2）、环面包果素（3）、柘树黄酮A（4）和C（5）。通过光谱方法鉴定了新化合物的结构。在对小鼠白血病P-388细胞进行细胞毒性评估时，新化合物的半数抑制浓度（IC50）为5.0微克/毫升。