Weddington W W, Haertzen C A, Hess J M, Brown B S
National Institute on Drug Abuse, Rockville, Maryland 20857.
Am J Drug Alcohol Abuse. 1991 Sep;17(3):355-68. doi: 10.3109/00952999109027558.
We compared retention in treatment and psychological reactions during drug abuse treatment by 22 HIV-antibody positive, physically asymptomatic cocaine addicts to 22 matched HIV-seronegative cocaine addicts. All subjects participated in an outpatient clinical research project. There were no significant differences between groups in sociodemographics and psychiatric symptom scores on entrance or cocaine use except for route of administration (chi 2 = 11.59, df = 2, p less than .005). There were no significant differences among groups regarding being informed of serostatus and beginning treatment. There was a trend (p = .079) for more seropositives to complete treatment. Using end-point analysis to compare 11 seropositive subjects who completed a minimum of 2 weeks of treatment to a matched seronegative comparison groups, there were no significant differences in mood states except for "anger/hostility" (interaction of group x time; F = 2.24, df = 13/260, p less than .05). Informing drug abusers in treatment regarding positive HIV-serostatus was not associated with a lower treatment-retention rate or adverse psychological reactions when counseling regarding HIV issues was integrated with drug abuse treatment.
我们将22名HIV抗体呈阳性、身体无症状的可卡因成瘾者与22名匹配的HIV血清阴性可卡因成瘾者在药物滥用治疗期间的治疗留存率和心理反应进行了比较。所有受试者均参与了一项门诊临床研究项目。除给药途径外（卡方 = 11.59，自由度 = 2，p < 0.005），两组在入组时的社会人口统计学和精神症状评分或可卡因使用情况方面无显著差异。在是否被告知血清状态及开始治疗方面，两组之间也无显著差异。血清阳性者完成治疗的人数有增加趋势（p = 0.079）。采用终点分析，将11名完成至少2周治疗的血清阳性受试者与匹配的血清阴性对照组进行比较，除“愤怒/敌意”外（组间×时间交互作用；F = 2.24，自由度 = 13/260，p < 0.05），情绪状态方面无显著差异。当将HIV问题咨询与药物滥用治疗相结合时，告知接受治疗的药物滥用者其HIV血清阳性状态与较低的治疗留存率或不良心理反应无关。
