Watanabe Norihiko, Takabayashi Katsuhiko
Division of Allergy and Clinical Immunology, Department of Clinical Cell Biology, Chiba University School of Medicine.
Nihon Rinsho. 2009 Mar;67(3):500-5.
Systemic lupus erythematosus (SLE) is a multisystem, autoimmune, connective-tissue disorder with a broad range of clinical presentations. SLE predominantly affects women, especially from ethnic groups with African and Asian ancestry. This disorder is a chronic illness that can be life threatening when major organs are affected, but more commonly results in debilitating condition and affects employment and fertility. This article summarizes the recent advances in our understanding of the genetics, epidemiology and pathogenesis of SLE. In addition, progress in the assessment and management of serious complications such as lupus nephritis and CNS lupus is reviewed. New therapeutic approaches, such as low-dose cyclophosphamide regimens, mycophenolate mofetil and biological agents are also discussed.
系统性红斑狼疮（SLE）是一种多系统自身免疫性结缔组织疾病，临床表现广泛。SLE主要影响女性，尤其是非洲和亚洲血统的种族群体。这种疾病是一种慢性病，当主要器官受到影响时可能危及生命，但更常见的是导致身体衰弱，影响就业和生育能力。本文总结了我们对SLE遗传学、流行病学和发病机制认识的最新进展。此外，还综述了狼疮性肾炎和中枢神经系统狼疮等严重并发症评估和管理方面的进展。还讨论了新的治疗方法，如低剂量环磷酰胺方案、霉酚酸酯和生物制剂。
