纤维肌痛患者体内氨基酸稳态的改变。
Altered amino acid homeostasis in subjects affected by fibromyalgia.
作者信息
Bazzichi Laura, Palego Lionella, Giannaccini Gino, Rossi Alessandra, De Feo Francesca, Giacomelli Camillo, Betti Laura, Giusti Laura, Mascia Giovanni, Bombardieri Stefano, Lucacchini Antonio
机构信息
Department of Internal Medicine, Division of Rheumatology, University of Pisa, Via Roma 67, 56126 Pisa, Italy.
出版信息
Clin Biochem. 2009 Jul;42(10-11):1064-70. doi: 10.1016/j.clinbiochem.2009.02.025. Epub 2009 Mar 10.
OBJECTIVES
To evaluate plasma amino acid (AA) concentrations in patients affected by fibromyalgia (FM) and to study the relationships between their levels and FM clinical parameters.
DESIGN AND METHODS
20 AAs were assessed in 34 FM patients and in 18 healthy volunteers by means of a modified version of the Waters picotag method.
RESULTS
Significant lower plasma taurine, alanine, tyrosine (Tyr), valine, methionine, phenylalanine and threonine concentrations, and the sum of essential AAs were observed in FM patients vs healthy controls (P<0.05). Tyr CAA' ratio and the sum of AAs competing with tryptophan for brain uptake were significantly reduced in FM (P<0.05). A significant correlation was found between FM clinical parameters and certain AAs.
CONCLUSIONS
Our results suggest probable defects of gut malabsorption of certain AAs in FM patients. Moreover, given the reduced Tyr CAA' ratio in FM patients, a possible impairment of the cathecolaminergic system in the FM syndrome may be suggested.
目的
评估纤维肌痛（FM）患者的血浆氨基酸（AA）浓度，并研究其水平与FM临床参数之间的关系。
设计与方法
采用改良的沃特斯氨基酸分析法，对34例FM患者和18名健康志愿者的20种氨基酸进行评估。
结果
与健康对照组相比，FM患者血浆中的牛磺酸、丙氨酸、酪氨酸（Tyr）、缬氨酸、蛋氨酸、苯丙氨酸和苏氨酸浓度以及必需氨基酸总和显著降低（P<0.05）。FM患者的Tyr CAA'比值以及与色氨酸竞争脑摄取的氨基酸总和显著降低（P<0.05）。FM临床参数与某些氨基酸之间存在显著相关性。
结论
我们的结果表明FM患者可能存在某些氨基酸肠道吸收不良的缺陷。此外，鉴于FM患者的Tyr CAA'比值降低，可能提示FM综合征中儿茶酚胺能系统存在可能的损害。
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