Department of Surgery, Odontostomatology and Maternal Sciences, Fibromyalgia Diagnosis and Treatment Centre, University of Verona, 37134 Verona, Italy.
Department of Surgery and Oncology, General and Pancreatic Surgery, Pancreas Institute, University of Verona Hospital Trust, 37134 Verona, Italy.
Nutrients. 2020 Mar 19;12(3):821. doi: 10.3390/nu12030821.
Fibromyalgia syndrome (FMS) is a chronic clinical condition characterized by pain, fatigue, altered sleep, and cognitive disturbances. The purpose of this study was to compare two alternative treatments (nutraceutical and acupuncture) in FMS patients through a randomized clinical trial.
A total of 60 FMS female patients were randomized for treatment with a nutritional combination containing coenzyme Q10, vitamin D, alpha-lipoic acid, magnesium, and tryptophan (Migratens Group) or acupuncture treatment (Acupuncture Group) performed according the principles of traditional Chinese medicine (TCM), both for 3 months. Changes in pain and in quality of life (QoL) measured with a Fibromyalgia Impact Questionnaire Score-Revised (FIQ-R) and the Fibromyalgia Severity Scale (FSS) were performed at 1, 3, and 6 months after the start of treatments.
A total of 55 patient completed the study (21 in the Migratens Group and 34 in the Acupuncture Group). Migratens treatment shows a statistically significant reduction of pain 1 month after the start of therapy (T1, p = 0.025), strengthened after 3 months with maintenance of treatment (p = 0.012). The efficacy in reducing pain was apparent in the Acupuncture Group at all post-treatment determinations and at follow-up (T1 and T2 p = <0.001). Regarding QoL, improvement in FIQ-R and FSS values was revealed in both groups.
The nutraceutical approach with Migratens seems to be an effective option to for patients with FMS. Our experience confirmed also the validity of acupuncture in these patients. Considering the complexity of the management of FMS patients, our results suggest a cyclical and sequential, or even concurrent treatment with different approaches, to improve the efficacy and the compliance of patients to long-term treatment.
纤维肌痛综合征（FMS）是一种以疼痛、疲劳、睡眠改变和认知障碍为特征的慢性临床疾病。本研究的目的是通过随机临床试验比较两种替代疗法（营养疗法和针灸）在 FMS 患者中的效果。
共 60 名 FMS 女性患者随机分为营养组合治疗组（Migratens 组）或针灸治疗组（Acupuncture 组），营养组合包含辅酶 Q10、维生素 D、α-硫辛酸、镁和色氨酸。两组均接受 3 个月的治疗。在治疗开始后 1、3 和 6 个月，使用修订后的纤维肌痛影响问卷评分（FIQ-R）和纤维肌痛严重程度量表（FSS）评估疼痛和生活质量（QoL）的变化。
共有 55 名患者完成了研究（Migratens 组 21 名，Acupuncture 组 34 名）。Migratens 治疗在治疗开始后 1 个月（T1，p = 0.025）时疼痛明显减轻，并在 3 个月时持续治疗后（p = 0.012）得到强化。在所有治疗后和随访时（T1 和 T2，p < 0.001），针灸组在减轻疼痛方面的疗效明显。两组的 FIQ-R 和 FSS 值均有所改善。
Migratens 的营养疗法似乎是 FMS 患者的有效选择。我们的经验还证实了针灸在这些患者中的有效性。考虑到 FMS 患者管理的复杂性，我们的结果表明，采用不同方法进行周期性、顺序性甚至同时治疗，可以提高疗效和患者对长期治疗的依从性。
