Suhrie Erin M, Hanlon Joseph T, Jaffe Emily J, Sevick Mary Ann, Ruby Christine M, Aspinall Sherrie L
Pharmacy Department, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.
Am J Geriatr Pharmacother. 2009 Feb;7(1):20-5. doi: 10.1016/j.amjopharm.2009.02.001.
There is a lack of studies concerning improvement of medication use in palliative care patients in nursing homes.
This study was conducted to evaluate whether a geriatric palliative care team reduced unnecessary medication prescribing for elderly veterans residing in a nursing home.
This was a retrospective, descriptive study of patients who died while residing in a geriatric palliative care unit between August 1, 2005, and July 31, 2007. Prescribed medications were evaluated using the Unnecessary Drug Use Measure, which contains 3 items from the Medication Appropriateness Index concerning lack of indication, lack of effectiveness, and therapeutic duplication. This measure was applied at 2 time points: on transfer/admission to the palliative care unit and at the last 30-day pharmacist medication review before death. Paired t tests and McNemar tests were used to compare medication use at these 2 points.
Eighty-nine patients were included in the study. The majority were male (97.8%) and white (78.7%), with a mean (SD) age of 79.7 (7.8) years. The median length of stay on the unit was 39.0 days, and the mean number of chronic medical conditions was 8.4 (4.3). At baseline, the mean number of scheduled medications was 9.7 (4.3). The number of unnecessary medications per patient decreased from a mean of 1.7 (1.5) at admission to 0.6 (0.8) at closeout (P = 0.003). The decrease was seen in all 3 categories of the Unnecessary Drug Use Measure.
The geriatric palliative care team was associated with a reduction in the number of unnecessary medications prescribed for older veterans in this nursing home. Future studies should evaluate the impact of decreasing unnecessary prescribing on clinical outcomes such as adverse drug reactions.
关于改善养老院姑息治疗患者用药情况的研究较少。
本研究旨在评估老年姑息治疗团队是否减少了居住在养老院的老年退伍军人不必要的药物处方。
这是一项对2005年8月1日至2007年7月31日期间在老年姑息治疗病房死亡的患者进行的回顾性描述性研究。使用不必要药物使用指标对处方药物进行评估,该指标包含药物适宜性指数中关于缺乏适应症、缺乏有效性和治疗重复的3个项目。该指标在两个时间点应用:转入/入住姑息治疗病房时以及死亡前最后一次30天的药剂师药物审查时。采用配对t检验和McNemar检验比较这两个时间点的用药情况。
89名患者纳入研究。大多数为男性(97.8%)和白人(78.7%),平均(标准差)年龄为79.7(7.8)岁。在病房的中位住院时间为39.0天,慢性疾病的平均数量为8.4(4.3)种。基线时,预定药物的平均数量为9.7(4.3)种。每位患者不必要药物的数量从入院时的平均1.7(1.5)种降至出院时的0.6(0.8)种(P = 0.003)。在不必要药物使用指标的所有3个类别中均出现了减少。
老年姑息治疗团队与该养老院老年退伍军人不必要药物处方数量的减少有关。未来的研究应评估减少不必要处方对诸如药物不良反应等临床结局的影响。