O'Connell K, Landman G, Farmer E, Edidin M
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Am J Pathol. 1991 Oct;139(4):743-9.
Injection into nude mice of a well-differentiated SV40 T-antigen-transformed murine endothelial cell (EC) line results in widespread invasive tumors confined to connective tissues. The tumors, which do not metastasize, consist of both host-derived cells and transformed EC, displaying histologic features typical of Kaposi's sarcoma (KS). Although the EC is believed to be the cell of origin in KS, this has not been proven and is the subject of debate. The unusual tumorigenicity of this transformed cell suggests that EC-specific gene products induced by SV40 T antigen may contribute to tumorigenesis by autocrine growth stimulation and recruitment of host cells. KS-like tumors may be the result of EC alteration by any virus that induces relevant EC-derived cytokines.
将一种高度分化的、经SV40 T抗原转化的鼠内皮细胞（EC）系注射到裸鼠体内，会导致局限于结缔组织的广泛侵袭性肿瘤。这些不发生转移的肿瘤由宿主来源的细胞和转化的EC组成，呈现出卡波西肉瘤（KS）典型的组织学特征。尽管EC被认为是KS的起源细胞，但这尚未得到证实，仍是一个有争议的话题。这种转化细胞不寻常的致瘤性表明，SV40 T抗原诱导的EC特异性基因产物可能通过自分泌生长刺激和宿主细胞募集而促进肿瘤发生。KS样肿瘤可能是任何诱导相关EC衍生细胞因子的病毒导致EC改变的结果。
