富含钒的灰树花的降血糖活性。

Hypoglycemic activity of Grifola frondosa rich in vanadium.

机构信息

College of Food and Bioengineering, Shandong Institute of Light Industry, Jinan, People's Republic of China.

出版信息

Biol Trace Elem Res. 2009 Nov;131(2):186-91. doi: 10.1007/s12011-009-8355-4. Epub 2009 Mar 13.

DOI:10.1007/s12011-009-8355-4

PMID:19283341

Abstract

The hypoglycemic activity of fermented mushroom of Grifola frondosa rich in vanadium (GFRV) was studied in this paper. Alloxan- and adrenalin-induced hyperglycemic mice were used in the study. The blood glucose and the HbA1c of the mice were analyzed respectively. After the mice were administered (ig) with GFRV, the blood glucose and the HbA1c of alloxan-induced hyperglycemic mice decreased (p < 0.05, p < 0.01) and ascension of blood glucose induced by adrenalin was inhibited (p < 0.01). Also, the bodyweight of the alloxan-induced hyperglycemic mice was increased gradually. In the fermented mushroom of G. frondosa, vanadium at lower doses in combination with G. frondosa induced significant decreases of the blood glucose and HbA1c levels in hyperglycemic mice.

摘要

本文研究了富含钒的灰树花发酵蘑菇（GFRV）的降血糖活性。研究中使用了链脲佐菌素和肾上腺素诱导的高血糖小鼠。分别分析了小鼠的血糖和 HbA1c。给 GFRV 灌胃后，可降低链脲佐菌素诱导的高血糖小鼠的血糖和 HbA1c（p<0.05，p<0.01），并抑制肾上腺素引起的血糖升高（p<0.01）。此外，还可逐渐增加链脲佐菌素诱导的高血糖小鼠的体重。在灰树花发酵蘑菇中，较低剂量的钒与灰树花结合可显著降低高血糖小鼠的血糖和 HbA1c 水平。