Nielsen Jørn Dalsgaard, Heslet Lars
Finsencentret, Haematologisk Klinik 4.
Ugeskr Laeger. 2009 Feb 16;171(8):610-1.
Heparin-induced immune-mediated thrombocytopenia (HIT) is a life-threatening complication of heparin treatment. When HIT is clinically suspected, heparin treatment should immediately be replaced with an alternative, fast-acting, anticoagulant agent, and blood tests should be carried out to verify or to exclude the diagnosis. Argatroban has recently been approved for HIT treatment in Denmark. Recommendations for dosing of argatroban in HIT patients with and without comorbities are presented.
肝素诱导的免疫介导性血小板减少症（HIT）是肝素治疗的一种危及生命的并发症。当临床上怀疑有HIT时，应立即用另一种速效抗凝剂替代肝素治疗，并进行血液检查以证实或排除诊断。阿加曲班最近在丹麦已被批准用于HIT治疗。本文给出了有合并症和无合并症的HIT患者阿加曲班给药的建议。
