Christoffersen Christina, Lethagen Stefan, Gøtze Jens Peter
Klinisk Biokemisk Afdeling, Rigshospitalet, DK-2100 København Ø.
Ugeskr Laeger. 2009 Feb 16;171(8):612-5.
Heparin treatment can cause an immune-mediated thrombocytopenia: HIT. HIT antibodies can be detected by various methods, but laboratory analyses are not specific or sensitive and may delay the diagnostic process. It is therefore important to initiate alternative treatment based on the clinical findings, and a clinical score system for evaluating the risk of HIT has been suggested. When HIT is likely, treatment consists of immediate replacement of heparin with alternative anticoagulation treatment and refrainment from warfarin therapy and platelet infusion.
肝素诱导的血小板减少症（HIT）。可通过多种方法检测HIT抗体，但实验室分析既不特异也不敏感，可能会延迟诊断过程。因此，根据临床发现启动替代治疗很重要，并且已经提出了一种用于评估HIT风险的临床评分系统。当可能发生HIT时，治疗包括立即用替代抗凝治疗替代肝素，并避免使用华法林治疗和血小板输注。
