Olesen Stine Chabert, Hansen Dorte Lindqvist, Almdal Thomas, Bendtsen Flemming, Nordgaard Inge, Hvolris Lisbeth Edvardsen, Holst Jens J, Naver Lars, Madsbad Sten
Hvidovre Hospital.
Ugeskr Laeger. 2009 Feb 16;171(8):615-7.
The resolution of diabetes after gastric bypass is already observed during the first days after the operation, while the control of diabetes after gastric banding occurs after weight loss. Other mechanisms than weight loss must therefore explain the improved glucose tolerance. Focus has been on appetite-regulating gut hormone, particularly peptide YY and glucagon-like peptide-1. Nevertheless, other unknown hormones or mechanisms may be involved in the dramatic changes in the glucose metabolism. Development of new drugs and treatments based on the endocrine changes observed after bariatric surgery with the aim of curing type 2-diabetes are warranted.
胃旁路手术后数天内即可观察到糖尿病缓解，而胃束带术后糖尿病的控制则在体重减轻后出现。因此，除体重减轻外，其他机制必定可以解释葡萄糖耐量的改善。人们一直将重点放在调节食欲的肠道激素上，尤其是肽YY和胰高血糖素样肽-1。然而，其他未知激素或机制可能也参与了葡萄糖代谢的显著变化。有必要基于减重手术后观察到的内分泌变化开发新药和新疗法，以治愈2型糖尿病。
