[类风湿关节炎中的皮肤利什曼病]
[Cutaneous leishmaniasis in rheumatoid arthritis].
作者信息
Hachicha I, Sellami M, Fourati H, Akrout R, Hdiji N, Baklouti S
机构信息
Service de rhumatologie, CHU Hédi Chaker, 3029 Sfax, Tunisia.
出版信息
Rev Med Interne. 2009 Jul;30(7):609-12. doi: 10.1016/j.revmed.2008.11.015. Epub 2009 Mar 12.
INTRODUCTION
Cutaneous leishmaniasis is a protozoal infection. Its prevalence is increasing, especially in immunocompromised subjects.
CASE REPORTS
We report four patients with rheumatoid arthritis, treated with methotrexate and prednisone who developed cutaneous leishmaniasis. Clinical outcome was favorable after institution of antimony therapy in three cases despite the continuation of methotrexate and prednisone. One patient failed to respond to therapy.
DISCUSSION
The frequency of cutaneous leishmaniasis is increasing especially in immunocompromised subjects. In our patients, rheumatoid arthritis, corticosteroid therapy and methotrexate were predisposing factors of cutaneous leishmaniasis.
引言
皮肤利什曼病是一种原生动物感染。其患病率正在上升，尤其是在免疫功能低下的人群中。
病例报告
我们报告了4例类风湿关节炎患者，他们在接受甲氨蝶呤和泼尼松治疗时患上了皮肤利什曼病。尽管继续使用甲氨蝶呤和泼尼松，但3例患者在开始使用锑剂治疗后临床结果良好。1例患者治疗无效。
讨论
皮肤利什曼病的发病率正在上升，尤其是在免疫功能低下的人群中。在我们的患者中，类风湿关节炎、皮质类固醇治疗和甲氨蝶呤是皮肤利什曼病的诱发因素。
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