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前列腺癌根治术后的辅助治疗:临床考量

Adjuvant therapy after radical prostatectomy: clinical considerations.

作者信息

Mitra A, Khoo V

机构信息

Clinical Research Fellow, Institute of Cancer Research, Sutton, Surrey, UK.

出版信息

Surg Oncol. 2009 Sep;18(3):247-54. doi: 10.1016/j.suronc.2009.02.005. Epub 2009 Mar 12.

DOI:10.1016/j.suronc.2009.02.005
PMID:19285386
Abstract

There are no standardised guidelines for the role of adjuvant radiotherapy post-prostatectomy. Evidence that may shed light into its appropriate usage is marred by the difficulty in defining adjuvant radiotherapy and failure of some studies to adequately distinguish it from salvage radiotherapy. The ability to identify which prostate cancers are likely to benefit from immediate post-operative radiotherapy would enable the judicious use of this modality and minimise the unnecessary exposure to its side-effects. This review outlines the pre- and post-surgical clinical considerations that form the discussion around the requirement for adjuvant therapy; radiotherapy, androgen deprivation therapy and chemotherapy. Principles for the use of local and systemic therapies are discussed.

摘要

前列腺切除术后辅助放疗的作用尚无标准化指南。由于难以定义辅助放疗以及一些研究未能充分将其与挽救性放疗区分开来,可能有助于明确其合理应用的证据受到了影响。确定哪些前列腺癌可能从术后即刻放疗中获益的能力,将有助于明智地使用这种治疗方式,并最大限度地减少不必要的副作用暴露。本综述概述了术前和术后的临床考虑因素,这些因素构成了围绕辅助治疗(放疗、雄激素剥夺治疗和化疗)需求的讨论。文中讨论了局部和全身治疗的使用原则。

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Adjuvant therapy after radical prostatectomy: clinical considerations.前列腺癌根治术后的辅助治疗:临床考量
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[Adjuvant medical treatment or radiotherapy following radical prostatectomy or curative radiotherapy].根治性前列腺切除术后或根治性放疗后的辅助性医学治疗或放疗
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Adjuvant and salvage radiotherapy after prostatectomy for prostate cancer: a literature review.前列腺癌前列腺切除术后的辅助性和挽救性放疗:文献综述
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[Pro and contra -- adjuvant therapy in locoregional advanced prostatic carcinoma after radical prostatectomy].[前列腺癌根治术后局部晚期前列腺癌辅助治疗的利弊]
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[Pro and contra -- adjuvant therapy in locoregional advanced prostatic carcinoma after radical prostatectomy].[前列腺癌根治术后局部晚期前列腺癌辅助治疗的利弊]
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[Radiotherapy for high-risk patients after radical prostatectomy for prostate cancer: immediate postoperative or salvage?].[前列腺癌根治性前列腺切除术后高危患者的放疗:术后即刻放疗还是挽救性放疗?]
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Does neoadjuvant hormone therapy improve outcome in prostate cancer patients receiving radiotherapy after radical prostatectomy?新辅助激素疗法能否改善前列腺癌患者在根治性前列腺切除术后接受放疗的预后?
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