Wu M H, Wei C C, Xu Z Y, Yuan H C, Lian W N, Yang Q J, Chen M, Jiang Q W, Wang C Z, Zhang S J
Department of Infectious Diseases, Hua Shan Hospital, Shanghai Medical University, People's Republic of China.
Am J Trop Med Hyg. 1991 Sep;45(3):345-9. doi: 10.4269/ajtmh.1991.45.345.
A randomized double-blind study comparing the therapeutic efficacy of single dose of levo-praziquantel and mixed isomer praziquantel was carried out on 139 matched pairs of patients with schistosomiasis japonica. A single dose of either levo-praziquantel (20 mg/kg) or praziquantel (40 mg/kg) was given to each patient. Four and six months after treatment, the stool ova negative conversion rates were 94.85% and 96.27% for the levo-praziquantel group, and 97.06% and 94.03% for the praziquantel group, respectively; there was no statistically significant difference between the two treatments (P greater than 0.05). For lightly and moderately infected patients, a single 20 mg/kg dose of levo-praziquantel was as efficacious as 40 mg/kg of praziquantel. Moreover, levo-praziquantel produced fewer side effects than praziquantel. These results suggest that levo-praziquantel is the component of the mixed isomer preparation that is antihelminthic. Levo-praziquantel could be used therapeutically at half the current dose of the mixed isomer drug.
对139对配对的日本血吸虫病患者进行了一项随机双盲研究，比较单剂量左旋吡喹酮和混合异构体吡喹酮的治疗效果。每位患者给予单剂量的左旋吡喹酮（20mg/kg）或吡喹酮（40mg/kg）。治疗后4个月和6个月，左旋吡喹酮组的粪便虫卵阴转率分别为94.85%和96.27%，吡喹酮组分别为97.06%和94.03%；两种治疗方法之间无统计学显著差异（P大于0.05）。对于轻度和中度感染患者，单剂量20mg/kg的左旋吡喹酮与40mg/kg的吡喹酮疗效相同。此外，左旋吡喹酮产生的副作用比吡喹酮少。这些结果表明，左旋吡喹酮是混合异构体制剂中的抗蠕虫成分。左旋吡喹酮可按混合异构体药物当前剂量的一半用于治疗。
