Trau H, Shpiro D, Schewach-Millet M, Pras M, Prelli F, Frangione B
Department of Dermatology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Am J Dermatopathol. 1991 Aug;13(4):414-7. doi: 10.1097/00000372-199108000-00014.
A nodular cutaneous amyloidosis biopsy specimen from a solitary nodule of a 75-year-old patient was characterized by amino terminal sequence analysis and was proved to be derived from immunoglobulin kIII light chain. Five years after the diagnosis of amyloidosis in the skin was made, a rectal biopsy demonstrated amyloid deposits in a blood vessel. It is suggested that nodular cutaneous amyloidosis is a slowly progressive systemic disease of the AL type, that manifest itself mainly in the skin.
对一名75岁患者单个结节的结节性皮肤淀粉样变活检标本进行氨基末端序列分析，结果表明其来源于免疫球蛋白κIII轻链。在皮肤淀粉样变诊断五年后，直肠活检显示血管中有淀粉样沉积物。提示结节性皮肤淀粉样变是一种缓慢进展的AL型全身性疾病，主要表现在皮肤。
