用蛋白质功能化的金纳米颗粒的纳米压痕

Nanoindentation of gold nanoparticles functionalized with proteins.

作者信息

Wampler Heeyeon P, Ivanisevic Albena

机构信息

Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States.

出版信息

Micron. 2009 Jun;40(4):444-8. doi: 10.1016/j.micron.2009.01.002. Epub 2009 Jan 31.

DOI:10.1016/j.micron.2009.01.002

PMID:19286387

Abstract

The hardness and Young's modulus of 10 and 20 nm gold nanoparticles (Au NPs) modified with bovine serum albumin and streptavidin were measured using a nanoindenter. The Au NPs were immobilized on a semiconductor surface through organic self-assembled monolayers. Changes in mechanical properties occurred when the Au NPs were immobilized on the surface. The hardness and Young's modulus were dependent on the size of the NPs, and the proteins on the particles showed highly plastic and elastic behavior compared to flat surfaces modified with self-assembled monolayers.

摘要

使用纳米压痕仪测量了用牛血清白蛋白和链霉亲和素修饰的10纳米和20纳米金纳米颗粒（Au NPs）的硬度和杨氏模量。Au NPs通过有机自组装单分子层固定在半导体表面。当Au NPs固定在表面时，其机械性能发生了变化。硬度和杨氏模量取决于纳米颗粒的尺寸，并且与用自组装单分子层修饰的平面相比，颗粒上的蛋白质表现出高度的塑性和弹性行为。