Messlinger Karl
Institute of Physiology and Pathophysiology, University of Erlangen-Nürnberg, Erlangen, Germany.
Exp Brain Res. 2009 Jun;196(1):179-93. doi: 10.1007/s00221-009-1756-y. Epub 2009 Mar 14.
Migraine is a complex neurological disease with a genetic background. Headache is the most prominent and clinically important symptom of migraine but its origin is still enigmatic. Numerous clinical, histochemical, electrophysiological, molecular and genetical approaches form a puzzle of findings that slowly takes shape. The generation of primary headaches like migraine pain seems to be the consequence of multiple pathophysiological changes in meningeal tissues, the trigeminal ganglion, trigeminal brainstem nuclei and descending inhibitory systems, based on specific characteristics of the trigeminovascular system. This contribution reviews the current discussion of where and how the migraine pain may originate and outlines the experimental work to answer these questions.
偏头痛是一种具有遗传背景的复杂神经系统疾病。头痛是偏头痛最突出且临床上最重要的症状，但其起源仍然成谜。众多临床、组织化学、电生理、分子和遗传学方法形成了一幅逐渐成形的研究结果拼图。基于三叉神经血管系统的特定特征，像偏头痛疼痛这样的原发性头痛的产生似乎是脑膜组织、三叉神经节、三叉神经脑干核以及下行抑制系统中多种病理生理变化的结果。本论文综述了当前关于偏头痛疼痛可能起源于何处以及如何产生的讨论，并概述了为回答这些问题所开展的实验工作。
