Nishino Jinju, Tanaka Sakae, Matsui Toshihiro, Mori Toshihito, Nishimura Keita, Eto Yoshito, Kaneko Atsushi, Saisho Koichiro, Yasuda Masayuki, Chiba Noriyuki, Yoshinaga Yasuhiko, Saeki Yukihiko, Seki Atsuhito, Tohma Shigeto
Nishino Clinic Orthopedics and Rheumatology, Nishigaoka, Kita-ku, Tokyo, Japan.
Mod Rheumatol. 2009;19(3):260-4. doi: 10.1007/s10165-009-0163-3. Epub 2009 Mar 14.
The purpose of this study was to describe the prevalence of total joint arthroplasty (TJA) in Japanese rheumatoid arthritis (RA) patients undergoing conventional drug treatment in a large observational cohort in Japan. A total of 5,177 RA patients were studied for the prevalence of TJA, who were enrolled in the NinJa database during the fiscal year of 2006. The cases of 2,695 RA patients with more than ten years of disease duration were extracted and subjected to further analysis. The prevalence of TJA increased in accordance with the disease duration, and the prevalence was markedly increased after ten years. Among the 2,695 patients with more than ten years of disease duration, 1,431 TJAs were performed in 645 (24.6%) patients. The patients with TJA had higher disease activity than those without TJA. In this cross-sectional study, TJAs were performed in approximately a quarter of the Japanese RA patients with more than ten years of disease duration. The result showed that patients with higher disease activity required TJA.
本研究的目的是描述在日本一个大型观察性队列中接受传统药物治疗的日本类风湿关节炎（RA）患者全关节置换术（TJA）的患病率。共有5177例RA患者被纳入研究以确定TJA的患病率，这些患者于2006财年被纳入NinJa数据库。提取了2695例病程超过十年的RA患者病例并进行进一步分析。TJA的患病率随病程增加，病程十年后患病率显著增加。在2695例病程超过十年的患者中，645例（24.6%）患者进行了1431次TJA。进行TJA的患者比未进行TJA的患者疾病活动度更高。在这项横断面研究中，病程超过十年的日本RA患者中约四分之一进行了TJA。结果表明，疾病活动度较高的患者需要进行TJA。
