Lacquaniti Antonio, Bolignano Davide, Campo Susanna, Perrone Carlo, Donato Valentina, Fazio Maria Rosaria, Buemi Antoine, Sturiale Alessio, Buemi Michele
Department of Internal Medicine, University of Messina, Messina, Italy.
Ren Fail. 2009;31(3):239-45. doi: 10.1080/08860220802669891.
Approximately one-third of all dialysis patients have mild to moderate malnutrition, while 6-8% have severe malnutrition, which is associated with increased morbidity and mortality rates and numerous pre-existing factors directly correlated with, or existing prior to, replacement hemodialysis. However, moderate to severe malnutrition (present in 10-30% of dialysis patients) is a prevalent cause of death among the elderly. Many of these patients have a particularly unstable cardiovascular and metabolic status that, independent of any underlying uremia and/or dialysis, impacts negatively on both their quality of life and clinical status. Moreover, their condition is often further exacerbated by dialysis itself, with its acute (e.g., hypotension and sensorial alterations) and chronic complications, including an exacerbation of malnutrition and systemic vascular disease. Malnutrition can occur secondary not only to erroneous dietary choices or uremia, but it may also depend on the patient's level of tolerance to dialysis and on the dialysis modality. Despite the improvements made to dialysis techniques, the nutritional condition of elderly patients on dialysis for chronic renal failure remains a cause for concern. In this patient category, it is therefore mandatory to ensure the daily supervision of nutritional status and early control when the first signs of malnutrition appear.
约三分之一的透析患者存在轻至中度营养不良,而6 - 8%的患者有严重营养不良,这与发病率和死亡率增加以及许多在替代血液透析之前就已存在或与之直接相关的因素有关。然而,中度至重度营养不良(在10 - 30%的透析患者中存在)是老年人中常见的死亡原因。这些患者中有许多人的心血管和代谢状况特别不稳定,这独立于任何潜在的尿毒症和/或透析,对他们的生活质量和临床状况都有负面影响。此外,透析本身及其急性(如低血压和感觉改变)和慢性并发症,包括营养不良和系统性血管疾病的加重,往往会使他们的病情进一步恶化。营养不良不仅可能继发于错误的饮食选择或尿毒症,还可能取决于患者对透析的耐受程度和透析方式。尽管透析技术有所改进,但慢性肾衰竭透析老年患者的营养状况仍然令人担忧。因此,对于这类患者,必须确保每日监测营养状况,并在出现营养不良的最初迹象时尽早进行控制。