Newman Stephen C, Bland Roger C
Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada.
Depress Anxiety. 2009;26(4):389-92. doi: 10.1002/da.20560.
There is a paucity of research on whether minor depression is a familial disorder.
We conducted a population-based family study of minor depression in which subjects were interviewed using the Diagnostic Interview Schedule (DIS). Minor depression only (MDO) was diagnosed if there was a lifetime history of what the DIS refers to as a depressive "spell" and no lifetime history of either Diagnostic and Statistical Manual of Mental Disorders, Third Edition, major depression or dysthymia. There were 71 probands with a lifetime history of MDO; 577 controls with no lifetime history of MDO, major depression, or dysthymia; and 1,539 first-degree relatives (FDRs). Logistic regression was performed with the presence/absence of MDO in a proband/control as the "exposure" and MDO in an FDR as the "outcome".
The odds ratio for the association between MDO in a proband and MDO in an FDR, after adjusting for age and sex of the FDR, was 1.55 (95% confidence interval: 0.93-2.58; P=.093). The study had 80% power to detect an odds ratio as small as 1.97, which is in the range of odds ratios seen for the familial aggregation of major depression.
MDO does not appear to be a familial disorder, raising questions about the validity of "minor depression" as a distinct psychiatric syndrome.
关于轻度抑郁症是否为家族性疾病的研究较少。
我们开展了一项基于人群的轻度抑郁症家族研究，使用诊断访谈表（DIS）对受试者进行访谈。如果受试者有DIS所指的抑郁“发作”终生史，且无《精神疾病诊断与统计手册》第三版中重度抑郁症或心境恶劣障碍的终生史，则诊断为单纯轻度抑郁症（MDO）。有71名终生患有MDO的先证者；577名无MDO、重度抑郁症或心境恶劣障碍终生史的对照者；以及1539名一级亲属（FDR）。以先证者/对照者中是否存在MDO作为“暴露因素”，以FDR中是否存在MDO作为“结局”进行逻辑回归分析。
在对FDR的年龄和性别进行校正后，先证者中MDO与FDR中MDO之间关联的优势比为1.55（95%置信区间：0.93 - 2.58；P = 0.093）。该研究有80%的把握度检测到低至1.97的优势比，这处于重度抑郁症家族聚集所见优势比的范围内。
MDO似乎不是家族性疾病，这引发了关于“轻度抑郁症”作为一种独特精神综合征有效性的质疑。
