加强钙黏蛋白与纤连蛋白基质之间的连接。

Tightening the connections between cadherins and fibronectin matrix.

作者信息

Hunt Geoffrey C, Schwarzbauer Jean E

机构信息

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

出版信息

Dev Cell. 2009 Mar;16(3):327-8. doi: 10.1016/j.devcel.2009.02.013.

DOI:10.1016/j.devcel.2009.02.013

PMID:19289079

Abstract

Fibronectin extracellular matrix is assembled and remodeled throughout embryogenesis and plays key roles in early vertebrate development. In this issue of Developmental Cell, Dzamba et al. reveal, through their studies of Xenopus embryos, a novel mechanism for regulating fibronectin matrix assembly through Wnt signaling and cadherin-mediated cell-cell adhesion.

摘要

纤连蛋白细胞外基质在整个胚胎发生过程中组装和重塑，并在脊椎动物早期发育中发挥关键作用。在本期《发育细胞》中，赞巴等人通过对非洲爪蟾胚胎的研究，揭示了一种通过Wnt信号传导和钙黏蛋白介导的细胞间黏附来调节纤连蛋白基质组装的新机制。