Bonkowsky Joshua L, Guenther Elisabeth, Srivastava Rajendu, Filloux Francis M
Division of Pediatric Neurology, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA.
J Child Neurol. 2009 Jun;24(6):709-13. doi: 10.1177/0883073808329532. Epub 2009 Mar 16.
The characteristics of seizures and epilepsy in infants who have had an apparent life-threatening event have been poorly defined. Our objective was to characterize in depth the cohort of patients with apparent life-threatening events who developed seizures. We collected data from infants hospitalized for an apparent life-threatening event, and evaluated patients for subsequent seizures or chronic epilepsy. Of 471 patients with an apparent life-threatening event, 25 (5.3%) had seizures and 17 (3.6%) developed chronic epilepsy. There was no increased risk for febrile seizures. Abnormal brain magnetic resonance imaging results and developmental delay were only found in those patients who developed chronic epilepsy. Of those who developed chronic epilepsy, 47% were diagnosed with seizures within 1 week of their apparent life-threatening event. The discharge diagnosis at the time of the apparent life-threatening event was poorly predictive of those who developed seizures. In most cases the cause of chronic epilepsy was unknown, although cortical dysplasias made up a significant percentage (12%).
有过明显危及生命事件的婴儿癫痫发作和癫痫的特征一直未得到明确界定。我们的目标是深入描述发生癫痫发作的明显危及生命事件患者队列。我们收集了因明显危及生命事件住院的婴儿的数据，并评估患者是否随后发生癫痫发作或慢性癫痫。在471例有明显危及生命事件的患者中，25例（5.3%）发生了癫痫发作，17例（3.6%）发展为慢性癫痫。热性惊厥风险没有增加。仅在那些发展为慢性癫痫的患者中发现了异常的脑磁共振成像结果和发育迟缓。在那些发展为慢性癫痫的患者中，47%在其明显危及生命事件后的1周内被诊断出癫痫发作。明显危及生命事件发生时的出院诊断对那些发生癫痫发作的患者预测性较差。在大多数情况下，慢性癫痫的病因不明，尽管皮质发育异常占相当比例（12%）。
