Christie P E, Smith C M, Lee T H
Department of Allergy and Allied, Guy's Hospital, London, United Kingdom.
Am Rev Respir Dis. 1991 Oct;144(4):957-8. doi: 10.1164/ajrccm/144.4.957.
We have determined the effect of prior inhalation of the LTD4 antagonist SK&F 104353 on the response to aspirin ingestion in six aspirin-sensitive asthmatic subjects (five women and one man 31 to 54 yr of age) in a randomized, double-blind, cross-over, placebo-controlled study. Pretreatment with inhaled SK&F 104353 (average nebulized dose, 893 micrograms) inhibited the response by a mean of 47% (p = 0.02). The inhibition was partial, ranging from 43 to 74% in five subjects. In the remaining subject, there was no effect of the drug on the asthmatic response. We conclude that the mechanism of aspirin-induced asthma is at least partially mediated by the leukotrienes in the majority of susceptible patients and that leukotriene antagonists may be useful in the treatment of aspirin-induced asthma.
在一项随机、双盲、交叉、安慰剂对照研究中，我们确定了预先吸入白三烯D4拮抗剂SK&F 104353对6名阿司匹林敏感型哮喘患者（5名女性和1名31至54岁男性）摄入阿司匹林后反应的影响。吸入SK&F 104353预处理（平均雾化剂量893微克）使反应平均抑制了47%（p = 0.02）。这种抑制是部分性的，5名受试者的抑制范围为43%至74%。在其余受试者中，该药物对哮喘反应没有影响。我们得出结论，在大多数易感患者中，阿司匹林诱发哮喘的机制至少部分由白三烯介导，白三烯拮抗剂可能对阿司匹林诱发哮喘的治疗有用。
