Yamaike Noritatsu, Tsujikawa Akitaka, Sakamoto Atsushi, Ota Masafumi, Kotera Yuriko, Miyamoto Kazuaki, Kita Mihori, Yoshimura Nagahisa
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Japan.
Retina. 2009 Jun;29(6):757-67. doi: 10.1097/IAE.0b013e31819d4fbf.
To evaluate the change in macular function after intravitreal injection of bevacizumab for the treatment of macular edema associated with retinal vein occlusion.
For this interventional case series, 20 eyes of 20 patients with macular edema associated with retinal vein occlusion were treated with an intravitreal injection of bevacizumab. Microperimetry in the macular area was performed with a Micro Perimeter 1 before and at 1, 3, and 6 months after treatment.
Improvement in macular function was detected immediately after treatment and lasted for at least 6 months. As measured by the Micro Perimeter 1, mean retinal sensitivities within the central 10 degrees field (4.9 +/- 2.7 dB at baseline) improved to 7.2 +/- 3.1 dB at 1 month, to 7.6 +/- 3.4 dB at 3 months, and to 7.7 +/- 3.9 dB at 6 months (P < 0.001). Of the 20 eyes, a recurrence of macular edema was observed in 14 (70%), but with the use of optical coherence tomography, integrity of the outer aspect of the foveal photoreceptors was detected at 3 months to 6 months in 15 (75%) eyes.
In eyes with macular edema associated with retinal vein occlusion, improvement in macular function was detected immediately after intravitreal injection of bevacizumab and lasted for at least 6 months.
评估玻璃体内注射贝伐单抗治疗视网膜静脉阻塞相关黄斑水肿后黄斑功能的变化。
在这个干预性病例系列研究中，对20例视网膜静脉阻塞相关黄斑水肿患者的20只眼进行玻璃体内注射贝伐单抗治疗。在治疗前以及治疗后1、3和6个月，使用Micro Perimeter 1对黄斑区域进行微视野检查。
治疗后立即检测到黄斑功能改善，且持续至少6个月。通过Micro Perimeter 1测量，中央10度视野内的平均视网膜敏感度（基线时为4.9±2.7 dB）在1个月时提高到7.2±3.1 dB，3个月时提高到7.6±3.4 dB，6个月时提高到7.7±3.9 dB（P<0.001）。20只眼中，14只（70%）观察到黄斑水肿复发，但使用光学相干断层扫描，在3至6个月时，15只（75%）眼检测到黄斑光感受器外层的完整性。
在视网膜静脉阻塞相关黄斑水肿的眼中，玻璃体内注射贝伐单抗后立即检测到黄斑功能改善，且持续至少6个月。
