多刺激响应性两亲性嵌段共聚物组装体
Multi-stimuli sensitive amphiphilic block copolymer assemblies.
作者信息
Klaikherd Akamol, Nagamani Chikkannagari, Thayumanavan S
机构信息
Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.
出版信息
J Am Chem Soc. 2009 Apr 8;131(13):4830-8. doi: 10.1021/ja809475a.
Abstract
Stimuli-responsive polymers are arguably the most widely considered systems for a variety of applications in biomedical arena. We report here a novel triple stimuli sensitive block copolymer assembly that responds to changes in temperature, pH and redox potential. Our block copolymer design constitutes an acid-sensitive THP-protected HEMA as the hydrophobic part and a temperature-sensitive PNIPAM as the hydrophilic part with an intervening disulfide bond. The micellar properties and the release kinetics of the encapsulated guest molecule in response to one stimulus as well as combinations of stimuli have been evaluated. Responsiveness to combination of stimuli not only allows for fine-tuning the guest molecule release kinetics, but also provides the possibility of achieving location-specific delivery.
摘要
刺激响应性聚合物可以说是生物医学领域各种应用中被广泛研究的系统。我们在此报告一种新型的三刺激敏感嵌段共聚物组装体，它对温度、pH值和氧化还原电位的变化有响应。我们的嵌段共聚物设计由一个酸敏感的THP保护的HEMA作为疏水部分和一个温度敏感的PNIPAM作为亲水部分组成，中间有一个二硫键。已经评估了胶束性质以及包封客体分子对一种刺激以及多种刺激组合的释放动力学。对多种刺激组合的响应不仅允许微调客体分子的释放动力学，还提供了实现定位特异性递送的可能性。
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