儿科抗风湿药物的最新进展：青少年特发性关节炎的治疗
Recent developments in anti-rheumatic drugs in pediatrics: treatment of juvenile idiopathic arthritis.
作者信息
Hayward Kristen, Wallace Carol A
机构信息
Division of Rheumatology, University of Washington School of Medicine, Seattle Children's Hospital, 4800 Sandpoint Way, NE MS R-5420, Seattle, WA 98105, USA.
出版信息
Arthritis Res Ther. 2009;11(1):216. doi: 10.1186/ar2619. Epub 2009 Feb 23.
Abstract
Juvenile idiopathic arthritis (JIA) is the most common autoimmune-autoinflammatory disease in childhood and affects approximately 1 in 1,000 children. Despite advances in diagnosis and treatment options, JIA remains a chronic condition for most affected children. Recent evidence suggests that disease control at onset may determine the tempo of subsequent disease course and long-term outcomes, and raises the concept of a therapeutic window of opportunity in patients with JIA. This underscores the importance of early aggressive treatment in patients with JIA. With the advent of novel biologic therapeutics, the repertoire of agents available for treatment of children with JIA has greatly increased. The present article will summarize recent developments in the medical treatment of children with JIA and will offer insights into emerging therapies.
摘要
幼年特发性关节炎（JIA）是儿童期最常见的自身免疫性-自身炎症性疾病，每1000名儿童中约有1人受影响。尽管在诊断和治疗选择方面取得了进展，但对大多数患病儿童来说，JIA仍然是一种慢性病。最近的证据表明，疾病在发病时的控制情况可能决定随后疾病进程的节奏和长期预后，并提出了JIA患者存在治疗机会窗的概念。这凸显了对JIA患者进行早期积极治疗的重要性。随着新型生物疗法的出现，可用于治疗JIA患儿的药物种类大幅增加。本文将总结JIA患儿医学治疗的最新进展，并对新兴疗法提供见解。
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