日本脑炎病毒和单纯疱疹病毒在小鼠脑内的实验性双重感染
Experimental double infection of Japanese encephalitis virus and herpes simplex virus in mouse brain.
作者信息
Hayashi K, Arita T
出版信息
Jpn J Exp Med. 1977 Feb;47(1):9-13.
In our laboratory, 64 autopsy cases of Japanese encephalitis patients were examined by immunofluorescence. Three patients showed some evidences of double infection of Japanese encephalitis virus and herpes simplex virus. Experiments were done to see the mechanisms of double infection. In doubly infected mice, Japanese encephalitis virus antigen was localized in the herpes simplex virus infected areas in the brain. These results suggested that "blood brain barrier" was broken by herpes simplex virus infection and Japanese encephalitis virus gained access to the susceptible cells.
在我们实验室，对64例日本脑炎患者的尸检病例进行了免疫荧光检查。3例患者显示出日本脑炎病毒和单纯疱疹病毒双重感染的一些证据。开展了实验以探究双重感染的机制。在双重感染的小鼠中，日本脑炎病毒抗原定位于脑中单纯疱疹病毒感染的区域。这些结果提示，单纯疱疹病毒感染破坏了“血脑屏障”，使得日本脑炎病毒得以进入易感细胞。
Zotero 插件