用一种简单灵敏的方法测定感染羊瘙痒病仓鼠脑组织中两性霉素B的浓度。
Measurement of the concentration of amphotericin B in brain tissue of scrapie-infected hamsters with a simple and sensitive method.
作者信息
Casaccia P, Ladogana A, Xi Y G, Ingrosso L, Pocchiari M, Silvestrini M C, Cittadini A
机构信息
Institute of General Pathology, Catholic University, Rome, Italy.
出版信息
Antimicrob Agents Chemother. 1991 Jul;35(7):1486-8. doi: 10.1128/AAC.35.7.1486.
Abstract
A simple, sensitive, and reproducible assay for the measurement of the amphotericin B concentration in tissue extracts was developed by using the fourth derivative of the absorption spectrum of amphotericin B between wavelengths of 330 and 430 nm. The amphotericin B concentration in spleen and brain was proportional to the total amount administered. The amphotericin B concentration in the brain was highly correlated with the increase in the mean incubation period of intracerebrally scrapie-infected hamsters.
摘要
通过利用两性霉素B在330至430纳米波长之间吸收光谱的四阶导数，开发出一种用于测量组织提取物中两性霉素B浓度的简单、灵敏且可重复的检测方法。脾脏和大脑中两性霉素B的浓度与给药总量成正比。大脑中两性霉素B的浓度与脑内感染羊瘙痒病仓鼠平均潜伏期的延长高度相关。
相似文献
1
Measurement of the concentration of amphotericin B in brain tissue of scrapie-infected hamsters with a simple and sensitive method.用一种简单灵敏的方法测定感染羊瘙痒病仓鼠脑组织中两性霉素B的浓度。
Antimicrob Agents Chemother. 1991 Jul;35(7):1486-8. doi: 10.1128/AAC.35.7.1486.
2
MS-8209, a new amphotericin B derivative, provides enhanced efficacy in delaying hamster scrapie.新型两性霉素B衍生物MS-8209在延缓仓鼠瘙痒病方面疗效更佳。
Antimicrob Agents Chemother. 1995 Dec;39(12):2810-2. doi: 10.1128/AAC.39.12.2810.
3
MS-8209, an amphotericin B analogue, delays the appearance of spongiosis, astrogliosis and PrPres accumulation in the brain of scrapie-infected hamsters.两性霉素B类似物MS - 8209可延缓瘙痒病感染仓鼠大脑中海绵状病变、星形胶质细胞增生和朊病毒蛋白（PrPres）积累的出现。
J Comp Pathol. 2000 Jan;122(1):3-8. doi: 10.1053/jcpa.1999.0338.
4
Amphotericin B delays both scrapie agent replication and PrP-res accumulation early in infection.两性霉素B在感染早期可延缓瘙痒病病原体的复制及抗蛋白酶K的朊蛋白（PrP-res）的积累。
J Virol. 1994 Nov;68(11):7534-6. doi: 10.1128/JVI.68.11.7534-7536.1994.
5
Amphotericin B: a novel class of antiscrapie drugs.
J Infect Dis. 1989 Nov;160(5):795-802. doi: 10.1093/infdis/160.5.795.
6
Amphotericin B delays the incubation period of scrapie in intracerebrally inoculated hamsters.
J Gen Virol. 1987 Jan;68 ( Pt 1):219-23. doi: 10.1099/0022-1317-68-1-219.
7
Effects of the polyene antibiotic derivative MS-8209 on the astrocyte lysosomal system of scrapie-infected hamsters.
J Mol Neurosci. 2002 Jun;18(3):271-81. doi: 10.1385/JMN:18:3:271.
8
High-performance liquid chromatographic analysis of amphotericin B in plasma, blood, urine and tissues for pharmacokinetic and tissue distribution studies.用于药代动力学和组织分布研究的血浆、血液、尿液和组织中两性霉素B的高效液相色谱分析。
J Chromatogr. 1992 Sep 2;579(2):259-68. doi: 10.1016/0378-4347(92)80390-c.
9
Increase of acidic fibroblast growth factor in the brains of hamsters infected with either 263K or 139H strains of scrapie.感染263K或139H毒株羊瘙痒病的仓鼠大脑中酸性成纤维细胞生长因子增加。
J Mol Neurosci. 2002 Jun;18(3):179-88. doi: 10.1385/JMN:18:3:179.
10
Increased multimeric mitochondrial DNA in the brain of scrapie-infected hamsters.感染羊瘙痒病的仓鼠大脑中多聚体线粒体DNA增加。
Intervirology. 1991;32(5):316-24. doi: 10.1159/000150214.
引用本文的文献
1
Stimulation of monocytes, macrophages, and microglia by amphotericin B and macrophage colony-stimulating factor promotes remyelination.两性霉素 B 和巨噬细胞集落刺激因子刺激单核细胞、巨噬细胞和小胶质细胞促进髓鞘再生。
J Neurosci. 2015 Jan 21;35(3):1136-48. doi: 10.1523/JNEUROSCI.1797-14.2015.
2
Late treatment with polyene antibiotics can prolong the survival time of scrapie-infected animals.用多烯抗生素进行后期治疗可延长羊瘙痒病感染动物的存活时间。
J Virol. 1997 Dec;71(12):9685-9. doi: 10.1128/JVI.71.12.9685-9689.1997.
3
Prions and related neurological diseases.朊病毒与相关神经疾病
Mol Aspects Med. 1994;15(3):195-291. doi: 10.1016/0098-2997(94)90042-6.
本文引用的文献
1
Treatment of murine cryptococcosis with liposome-associated amphotericin B.脂质体两性霉素B治疗小鼠隐球菌病
J Infect Dis. 1982 May;145(5):748-52. doi: 10.1093/infdis/145.2.748.
2
An internally-standardized assay for amphotericin B in tissues and plasma.
J Chromatogr. 1983 May 13;274:271-9. doi: 10.1016/s0378-4347(00)84430-8.
3
Treatment and prophylaxis of disseminated infection due to Candida albicans in mice with liposome-encapsulated amphotericin B.脂质体包裹两性霉素B对小鼠白色念珠菌播散感染的治疗与预防
J Infect Dis. 1983 May;147(5):939-45. doi: 10.1093/infdis/147.5.939.
4
Distribution of doubly radiolabelled amphotericin B methyl ester and amphotericin B in the non-human primate, Macaca mulatta.双放射性标记的两性霉素B甲酯和两性霉素B在食蟹猴（猕猴）体内的分布情况。
J Antimicrob Chemother. 1980 Mar;6(2):241-9. doi: 10.1093/jac/6.2.241.
5
Combination of oral flucytosine and ketoconazole as therapy for experimental cryptococcal meningitis.口服氟胞嘧啶与酮康唑联合治疗实验性隐球菌性脑膜炎
J Infect Dis. 1984 Apr;149(4):584-90. doi: 10.1093/infdis/149.4.584.
6
Antifungal agents useful in therapy of systemic fungal infections.可用于全身性真菌感染治疗的抗真菌药物。
Annu Rev Pharmacol Toxicol. 1983;23:303-30. doi: 10.1146/annurev.pa.23.040183.001511.
7
A pharmacologic guide to the clinical use of amphotericin B.两性霉素B临床应用的药理学指南
J Infect Dis. 1969 Oct;120(4):427-36. doi: 10.1093/infdis/120.4.427.
8
Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Diagnostic features and outcome of treatment.获得性免疫缺陷综合征患者的隐球菌病。诊断特征与治疗结果。
Ann Intern Med. 1986 Feb;104(2):234-40. doi: 10.7326/0003-4819-104-2-234.
9
Sensitive high-pressure liquid chromatographic assay for amphotericin B which incorporates an internal standard.结合内标的两性霉素B灵敏高效液相色谱测定法。
Antimicrob Agents Chemother. 1986 Apr;29(4):584-8. doi: 10.1128/AAC.29.4.584.
10
High-performance liquid chromatographic determination of amphotericin B in human serum.高效液相色谱法测定人血清中的两性霉素B
J Chromatogr. 1987 Aug 7;419:401-7. doi: 10.1016/0378-4347(87)80307-9.
Zotero 插件