Cartwright L E, Lambert J, McKenzie D R, Suchowerska N
School of Physics, The University of Sydney, NSW 2006, Australia.
Phys Med Biol. 2009 Apr 7;54(7):2217-27. doi: 10.1088/0031-9155/54/7/024. Epub 2009 Mar 17.
Fibre optic scintillation dosimeters, consisting of a plastic scintillator coupled to an optical fibre, are a promising dosimeter in brachytherapy applications. The combination of tissue equivalence, real-time readout and small spatial size makes them especially attractive for in vivo verification of patient treatments. Given that the orientation of the dosimeter with respect to the radioactive source changes during brachytherapy treatment, the angular dependence of the dosimeter is important. We derived the dependence of the response of a cylindrical dosimeter to a point radiation source as a function of distance along its axis and along a radius. Using the results, the effective point of measurement of a cylindrical scintillator was located for two points in the angular response curve as a function of distance between the source and dosimeter. We measured the angular response experimentally for a cylindrical scintillation dosimeter, when the source was located at a distance of 50 mm from the centre of the scintillator. A refinement of the design, in which a radio-opaque marker is incorporated into the tip for accurate localization in the patient, modifies the angular response of the dosimeter. For this new dosimeter design, we show that the dosimeter response decreases by 20% when the source is located on the axis of the scintillator, due to absorption by the marker. The dosimeter response becomes almost angle independent at 10 degrees away from the axis. Excluding this cone, a cylindrical scintillation dosimeter which incorporates a radio-opaque marker was found to be angle independent to within 2%. In most clinical brachytherapy applications, this design has an acceptable angular dependence.
光纤闪烁剂量计由与光纤耦合的塑料闪烁体组成,是近距离放射治疗应用中一种很有前景的剂量计。组织等效性、实时读数和小空间尺寸的结合使其在患者治疗的体内验证方面特别有吸引力。鉴于在近距离放射治疗过程中剂量计相对于放射源的方向会发生变化,剂量计的角度依赖性很重要。我们推导了圆柱形剂量计对点辐射源的响应与沿其轴线和半径的距离的函数关系。利用这些结果,确定了圆柱形闪烁体在角响应曲线中两个点的有效测量点,作为源与剂量计之间距离的函数。当源位于距闪烁体中心50毫米处时,我们对圆柱形闪烁剂量计的角响应进行了实验测量。一种改进设计,即在尖端加入不透射线标记以在患者体内准确定位,改变了剂量计的角响应。对于这种新的剂量计设计,我们表明当源位于闪烁体轴线上时,由于标记的吸收,剂量计响应降低了20%。在距轴线10度处,剂量计响应几乎与角度无关。排除这个圆锥区域,发现带有不透射线标记的圆柱形闪烁剂量计在2%的范围内与角度无关。在大多数临床近距离放射治疗应用中,这种设计具有可接受的角度依赖性。