Department of Pathology, Zhejiang Provincal People's Hospital, 158 shangtang road, 310014, Hangzhou, China.
Pathol Oncol Res. 2009 Dec;15(4):589-96. doi: 10.1007/s12253-009-9158-9. Epub 2009 Mar 18.
In order to identify reliable molecular markers for prognostic prediction in gastric carcinoma, we evaluated the expression of six molecular markers, namely bFGF, IGF-2, HGF, MMP-9, integrin beta3 and uPA in gastric cancer. There was a significant correlation between the expression of these markers and the depth of tumor invasion, vessel invasion, lymph node and distant metastasis, TNM stage and microvessel density. The average survival time and 5-year survival rate of patients with positive expression of molecular markers was higher than those with negative expression. Multivariate analysis showed that abnormal expression of bFGF, MMP-9 and uPA, as well as depth of invasion, lymph node and distant metastasis and TNM stage were independently related to poor prognosis of gastric cancer. MMP-9, bFGF and uPA are potential candidates for development as clinically applicable molecular prognostic markers for gastric carcinoma, and may be effective therapeutic targets for the disease in the future.
为了鉴定胃癌预后预测的可靠分子标志物，我们评估了六种分子标志物（bFGF、IGF-2、HGF、MMP-9、整合素β3 和 uPA）在胃癌中的表达。这些标志物的表达与肿瘤浸润深度、血管侵犯、淋巴结和远处转移、TNM 分期和微血管密度均有显著相关性。分子标志物阳性表达的患者平均生存时间和 5 年生存率均高于阴性表达的患者。多因素分析表明，bFGF、MMP-9 和 uPA 的异常表达以及浸润深度、淋巴结和远处转移和 TNM 分期与胃癌的不良预后独立相关。MMP-9、bFGF 和 uPA 是作为胃癌临床应用分子预后标志物开发的潜在候选标志物，未来可能成为该疾病有效的治疗靶点。
