Hamaguchi Tetsuya
General Inpatient Division, National Cancer Center Hospital.
Gan To Kagaku Ryoho. 2009 Mar;36(3):372-6.
Various attempts are under way to apply nanotechnology, in which remarkable progress has been made in recent years, to the diagnosis and treatment of cancer. For treating solid tumors, a system has been developed for more efficiently delivering nano-scale polymeric formulations to the tumors, utilizing the Enhanced Permeability and Retention( EPR)effect due to the characteristics of the tumor vascular system. Such nano-scale devices include a liposomal formulation, albumin-bound formulation and polymer micellar formulation, and each is currently under clinical development; some of these, such as doxorubicin-containing liposome(Doxyl), are already used in clinical practice. This paper describes the characterization of these nano-scale devices and ongoing clinical trials.
人们正在进行各种尝试，将近年来取得显著进展的纳米技术应用于癌症的诊断和治疗。为了治疗实体瘤，已经开发出一种系统，利用肿瘤血管系统的特性所产生的增强渗透和滞留（EPR）效应，更有效地将纳米级聚合物制剂递送至肿瘤。这类纳米级装置包括脂质体制剂、白蛋白结合制剂和聚合物胶束制剂，目前每种制剂都处于临床开发阶段；其中一些制剂，如含阿霉素脂质体（Doxyl），已在临床实践中使用。本文描述了这些纳米级装置的特性以及正在进行的临床试验。
