Sivamani Raja K, Maibach Howard I
School of Medicine, University of California, Davis, CA, USA.
J Dermatolog Treat. 2009;20(4):186-9. doi: 10.1080/09546630802683868.
BACKGROUND/AIMS: Human skin, exposed to a plethora of environmental insults that lead to free radicals and free radical damage, is equipped with an endogenous set of antioxidants, but these systems can become overwhelmed. Much study has focused on the therapeutic role of topical antioxidants but only a few investigate the utility of fruit extracts. Fruits are a rich source of diverse antioxidants and this article reviews their use for topical antioxidant protection.
MEDLINE searches from 1966 to August 2008 and EMBASE searches from January 1974 through August 2008 were conducted for articles in English. In vitro and in vivo studies of fruit extracts used specifically with skin tissue or skin cells were selected for review.
Fruits show diverse antioxidant activity in vitro and upon topical use in vivo. Studies have focused on antioxidant activity against reactive oxygen species (ROS) and ROS-induced signaling cascades. However, there has been little study regarding activity against reactive nitrogen or carbonyl species. Fruits may serve as a versatile source of antioxidants that can be harnessed for topical use. Several studies have shown efficacy in human in vivo studies and future studies will elucidate the versatility and clinical use of fruit extracts.
背景/目的：人类皮肤暴露于大量导致自由基及自由基损伤的环境侵害因素中，自身具备一套内源性抗氧化剂系统，但这些系统可能不堪重负。许多研究聚焦于局部抗氧化剂的治疗作用，不过仅有少数研究探讨了水果提取物的效用。水果富含多种抗氧化剂，本文综述其在局部抗氧化保护方面的应用。
检索了1966年至2008年8月的MEDLINE数据库以及1974年1月至2008年8月的EMBASE数据库中的英文文章。选取了专门针对皮肤组织或皮肤细胞使用水果提取物的体外和体内研究进行综述。
水果在体外及局部用于体内时均表现出多样的抗氧化活性。研究主要集中在针对活性氧（ROS）及ROS诱导的信号级联反应的抗氧化活性。然而，针对活性氮或羰基化合物的活性研究较少。水果可作为一种多功能的抗氧化剂来源，用于局部应用。多项人体体内研究已显示出其有效性，未来的研究将阐明水果提取物的多功能性及临床应用。
