Kongsgaard Ulf E, Werner Mads U
Department of Anaesthesia and Intensive Care, The Norwegian Radium Hospital, Rikshospitalet, Faculty of Medicine, University of Oslo, Oslo, Norway.
J Pain Palliat Care Pharmacother. 2009;23(1):48-50. doi: 10.1080/15360280902728237.
Randomized controlled trials provide the best evidence for the safety and effectiveness of interventions. However, the reliance on this study design as the only criterion for credible evidence is not possible in all areas of palliative medicine. Although we must exercise caution in making definitive claims from uncontrolled trial data, limitations in performing controlled trials should neither preclude the use of findings from well-designed nonrandomized controlled trials nor, more importantly, deprive patients of potentially effective treatments.
随机对照试验为干预措施的安全性和有效性提供了最佳证据。然而，在姑息医学的所有领域，仅将这种研究设计作为可靠证据的唯一标准是不可能的。尽管我们在根据非对照试验数据做出明确断言时必须谨慎，但开展对照试验的局限性既不应排除使用设计良好的非随机对照试验的结果，更重要的是，也不应剥夺患者接受潜在有效治疗的机会。
