Tondeleir Davina, Vandamme Drieke, Vandekerckhove Joël, Ampe Christophe, Lambrechts Anja
Department of Medical Protein Research, Flanders Interuniversity Institute for Biotechnology (VIB), Albert Baertsoenkaai 3, Ghent, Belgium.
Cell Motil Cytoskeleton. 2009 Oct;66(10):798-815. doi: 10.1002/cm.20350.
The dynamic actin cytoskeleton, consisting of six actin isoforms in mammals and a variety of actin binding proteins is essential for all developmental processes and for the viability of the adult organism. Actin isoform specific functions have been proposed for muscle contraction, cell migration, endo- and exocytosis and maintaining cell shape. However, these specific functions for each of the actin isoforms during development are not well understood. Based on transgenic mouse models, we will discuss the expression patterns of the six conventional actin isoforms in mammals during development and adult life. Ablation of actin genes usually leads to lethality and affects expression of other actin isoforms at the cell or tissue level. A good knowledge of their expression and functions will contribute to fully understand severe phenotypes or diseases caused by mutations in actin isoforms.
动态肌动蛋白细胞骨架由哺乳动物中的六种肌动蛋白异构体和多种肌动蛋白结合蛋白组成，对所有发育过程和成年生物体的生存能力至关重要。已经提出肌动蛋白异构体具有特定功能，如肌肉收缩、细胞迁移、胞吞和胞吐作用以及维持细胞形状。然而，在发育过程中每种肌动蛋白异构体的这些特定功能尚未得到充分了解。基于转基因小鼠模型，我们将讨论六种传统肌动蛋白异构体在哺乳动物发育和成年期的表达模式。肌动蛋白基因的缺失通常会导致致死性，并在细胞或组织水平上影响其他肌动蛋白异构体的表达。深入了解它们的表达和功能将有助于全面理解由肌动蛋白异构体突变引起的严重表型或疾病。
