Yue Chunlin, Wu Tiejun, Deng Weiming, Wang Guoxiang, Sun Xuechuan
Institute of Biomedical Engineering, West China Medical Center, SichuanUniversity, Chengdu, China.
Neuroreport. 2009 Mar 25;20(5):521-4. doi: 10.1097/wnr.0b013e328317f3b1.
We further support the notion that the catechol-O-methyltransferase (COMT) polymorphism may play a role in cognitive function. A continuous visual 3-back numerical working memory task was performed for an hour among 21 patients with different COMT genotypes. P300 visual event-related potentials evoked from the 3-back task were first utilized to observe the relationship between this COMT polymorphism and cortical physiology. The results showed that Val/Met heterozygous individuals show poorer performance, lower P300 amplitude, and higher P300 latency than those bearing the Val/Val homozygote on the task. This visual 3-back paradigm is a promising tool to examine continuous working memory capacity. The role of the COMT gene in dopamine catabolism makes for the influence of COMT polymorphism on P300 endophenotypes.
我们进一步支持这样一种观点，即儿茶酚-O-甲基转移酶（COMT）基因多态性可能在认知功能中发挥作用。对21名具有不同COMT基因型的患者进行了为期一小时的连续视觉3-back数字工作记忆任务。首先利用从3-back任务诱发的P300视觉事件相关电位来观察这种COMT基因多态性与皮质生理学之间的关系。结果显示，在该任务中，Val/Met杂合个体比携带Val/Val纯合子的个体表现更差、P300波幅更低且P300潜伏期更长。这种视觉3-back范式是一种用于检测连续工作记忆能力的有前景的工具。COMT基因在多巴胺分解代谢中的作用导致了COMT基因多态性对P300内表型的影响。
