Barrios Vivencio, Escobar Carlos, Echarri Rocio
Department of Cardiology, Hospital Ramón y Cajal, Madrid, Spain.
Fundam Clin Pharmacol. 2009 Apr;23(2):259-60. doi: 10.1111/j.1472-8206.2009.00683.x. Epub 2009 Mar 9.
Medication adherence is crucial to improve the prognosis of patients with hypertension. Importantly, the variables associated with antihypertensive medication withdrawal do not occur immediately after the cessation, but likely in the following years. Nevertheless, since the current randomized clinical trials are limited to a short or mid follow-up, the results provided from these studies cannot exactly reflect the importance of the therapy discontinuation. We discuss about two recent examples, the ONTARGET and the TRANSCEND trials, in which the inclusion of the discontinuation rates in the primary analysis change the results of these studies and subsequently, the interpretation of the data.
药物依从性对于改善高血压患者的预后至关重要。重要的是，与停用抗高血压药物相关的变量并非在停药后立即出现，而是可能在接下来的几年中出现。然而，由于目前的随机临床试验仅限于短期或中期随访，这些研究提供的结果不能准确反映治疗中断的重要性。我们讨论两个最近的例子，即ONTARGET试验和TRANSCEND试验，其中在主要分析中纳入停药率改变了这些研究的结果，进而改变了数据的解释。
