Public Health School of Central South University, Changsha 410078, Hunan Province, China.
Trans R Soc Trop Med Hyg. 2009 Aug;103(8):779-84. doi: 10.1016/j.trstmh.2009.02.015. Epub 2009 Mar 18.
The aims of this study were to explore the dose-response relationship between high-risk human papillomavirus (hrHPV) load and cervical lesions; the relationship between hrHPV viral load and the severity of cervical lesions; and the clinical application of the hybrid capture II (HC-II) system in the secondary prevention of cervical cancer. HrHPV viral load was detected by the HC-II system and cervical lesions were diagnosed from biopsied tissue. Curve estimation and Mantel trend analysis were used to explore the dose-response relationship between hrHPV viral load and cervical lesions. Spearman's rank correlation analysis and ordinal regression model were used for the analysis of hrHPV viral load and the severity of cervical lesions. Curve estimation showed good correlation between cervical lesion rates and hrHPV viral load (r=0.775, P=0.008); the rate of cervical lesions increased with hrHPV viral load (chi(trend)=8.000, P<0.001). Medium intensity rank correlation was found between hrHPV viral load grades and the severity of cervical lesions (r(s)=0.321, P<0.001); a correlation appeared between hrHPV viral load and the severity of cervical lesions (P<0.001). These results suggest a dose-response relationship between hrHPV viral load and the severity of cervical lesions. This dependence has important clinical applications and shows the potential value of the HC-II system in cervical cancer prevention.
本研究旨在探讨高危型人乳头瘤病毒（hrHPV）载量与宫颈病变之间的剂量-反应关系；hrHPV 病毒载量与宫颈病变严重程度之间的关系；以及杂交捕获 II（HC-II）系统在宫颈癌二级预防中的临床应用。采用 HC-II 系统检测 hrHPV 病毒载量，对活检组织进行宫颈病变诊断。采用曲线估计和 Mantel 趋势分析探讨 hrHPV 病毒载量与宫颈病变之间的剂量-反应关系。采用 Spearman 秩相关分析和有序回归模型分析 hrHPV 病毒载量与宫颈病变严重程度的关系。曲线估计显示宫颈病变发生率与 hrHPV 病毒载量之间存在良好的相关性（r=0.775，P=0.008）；宫颈病变发生率随 hrHPV 病毒载量的增加而增加（chi(trend)=8.000，P<0.001）。hrHPV 病毒载量等级与宫颈病变严重程度之间存在中等强度秩相关（r(s)=0.321，P<0.001）；hrHPV 病毒载量与宫颈病变严重程度之间存在相关性（P<0.001）。这些结果提示 hrHPV 病毒载量与宫颈病变严重程度之间存在剂量-反应关系。这种依赖性具有重要的临床应用价值，表明 HC-II 系统在宫颈癌预防中的潜在价值。
