Ameen Mahreen
St John's Institute of Dermatology, Guy's and St Thomas' Hospital, Westminister Bridge Road, London, SEI 7EH, UK.
Trop Doct. 2009 Apr;39(2):66-8. doi: 10.1258/td.2008.080151.
Mycetomas are chronic, granulomatous, subcutaneous infections caused by traumatic inoculation into the skin of either the actinomycetes bacteria or the eumycetes fungi, giving rise to actinomycetomas and eumycetomas, respectively. They are endemic in the tropics afflicting mainly those of low socio-economic status and men working in agriculture. The disease is slowly progressive and can cause bone involvement, which can result in considerable disability. Late presentation is not uncommon making them notoriously difficult to manage. This article highlights the important aspects of their management and developments in drug therapy.
足菌肿是由放线菌或真菌外伤性接种到皮肤引起的慢性、肉芽肿性皮下感染,分别导致放线菌性足菌肿和真菌性足菌肿。它们在热带地区流行,主要影响社会经济地位较低的人群和从事农业工作的男性。这种疾病进展缓慢,可导致骨骼受累,进而造成相当程度的残疾。就诊延迟并不罕见,这使得它们 notoriously 难以治疗。本文重点介绍了其治疗的重要方面以及药物治疗的进展。 (注:notoriously 直译为“臭名昭著地”,这里结合语境意译为“极其、非常”更合适)