Kohen Izchak, Sarcevic Adnan
Geriatric Psychiatry Division, North Shore-Long Island Jewish Health System, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA.
Am J Ther. 2009 Mar-Apr;16(2):197-8. doi: 10.1097/MJT.0b013e318186380b.
We report a case of central sleep apnea in a geriatric patient that was associated with treatment with aripiprazole for an episode of major depressive disorder with psychotic features. The patient was a 72-year-old man who was started on aripiprazole and developed central sleep apnea that improved significantly when the medication was stopped. A rechallenge with aripiprazole led to a worsening of the central sleep apnea, which again improved off the aripiprazole. We postulate that the central sleep apnea was due to aripiprazole. There have been numerous case reports in the literature of obstructive sleep apnea associated with atypical antipsychotics. To our knowledge, this is the first published case of central sleep apnea. We caution clinicians to be aware that there is potential risk of atypical antipsychotics like aripiprazole inducing or exacerbating central sleep apnea.
我们报告了一例老年患者的中枢性睡眠呼吸暂停病例，该病例与使用阿立哌唑治疗伴有精神病性特征的重度抑郁症发作有关。患者为一名72岁男性，开始使用阿立哌唑后出现中枢性睡眠呼吸暂停，停药后病情显著改善。再次使用阿立哌唑导致中枢性睡眠呼吸暂停恶化，停用阿立哌唑后病情又有所改善。我们推测中枢性睡眠呼吸暂停是由阿立哌唑引起的。文献中有大量关于非典型抗精神病药物与阻塞性睡眠呼吸暂停相关的病例报告。据我们所知，这是首例发表的中枢性睡眠呼吸暂停病例。我们提醒临床医生注意，像阿立哌唑这样的非典型抗精神病药物有诱发或加重中枢性睡眠呼吸暂停的潜在风险。
