Yen Y T, Wu R T, Tang S J, Wang F F
Institute of Biochemistry, Yang-Ming Medical College, Taipei, Taiwan.
Biochem Biophys Res Commun. 1991 Sep 30;179(3):1241-6. doi: 10.1016/0006-291x(91)91705-h.
The effect of hemin or podophyllotoxin on the differentiation of the erythropoietin (epo)-producing IW32 erythroleukemia cells was investigated. Podophyllotoxin induced IW32 cells to differentiate, and hemin potentiated the differentiation. Hemin had no effect on cell proliferation whereas podophyllotoxin inhibited cell growth. c-myc mRNA levels decreased biphasically by hemin or podophyllotoxin, while the combined treatment of hemin plus podophyllotoxin did not result in the initial decrease in c-myc mRNA level. Our data suggested that down-regulation of c-myc expression was not a prerequisite of IW32 cell differentiation induced by hemin and podophyllotoxin combined.
研究了氯高铁血红素或鬼臼毒素对产生促红细胞生成素（EPO）的IW32红白血病细胞分化的影响。鬼臼毒素诱导IW32细胞分化，氯高铁血红素增强了这种分化。氯高铁血红素对细胞增殖没有影响，而鬼臼毒素抑制细胞生长。氯高铁血红素或鬼臼毒素使c-myc mRNA水平呈双相下降，而氯高铁血红素加鬼臼毒素的联合处理并未导致c-myc mRNA水平的初始下降。我们的数据表明，c-myc表达的下调不是氯高铁血红素和鬼臼毒素联合诱导IW32细胞分化的先决条件。
