Hellström K E, Hellström I
Natl Cancer Inst Monogr. 1976 Nov;44:131-4.
Evidence is discussed from three animal systems (Shope papillomas in rabbits, Moloney sarcomas in mice, Schmidt-Ruppin-Rous sarcomas in Japanese quail) that immune reactions can be important in spontaneous tumor regression. In vitro studies performed in these systems indicate that blocking serum factors can thwart cell-mediated immune responses and that "unblocking" antibodies are often found in animals whose tumors have regressed. To what extent spontaneous regressions of human neoplasms are due to immunologic mechanisms is unknown; in 2 patients who had undergone spontaneous tumor regression, tumor cell cytotoxic lymphocytes and unblocking serum factors were detected. Better animal models and better knowledge about the mechanisms of tumor immune reactions are needed before tumor regression can be more successfully induced by immunologic manipulation (to what extent that will even be feasible in man is unknown).
从三种动物模型（兔的肖普乳头瘤、小鼠的莫洛尼肉瘤、日本鹌鹑的施密特-鲁平-劳斯肉瘤）中获取的证据表明，免疫反应在肿瘤的自发消退中可能起重要作用。在这些模型中进行的体外研究表明，封闭血清因子可抑制细胞介导的免疫反应，并且在肿瘤已消退的动物体内常可发现“解封”抗体。人类肿瘤的自发消退在多大程度上归因于免疫机制尚不清楚；在2例肿瘤自发消退的患者中，检测到了肿瘤细胞细胞毒性淋巴细胞和解封血清因子。在通过免疫操作更成功地诱导肿瘤消退之前（在人类中这在多大程度上可行尚不清楚），需要更好的动物模型以及对肿瘤免疫反应机制有更深入的了解。
