Buasang Kritsana, Taneepanichskul Surasak
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 2009 Mar;92(3):301-7.
To evaluate the efficacy of celecoxib and placebo for controlling irregular uterine bleeding in Jadelle users.
Randomized double blind placebo controlled trial.
Family Planning Clinic, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Forty Jadelle users with irregular bleeding were randomly allocated into two groups. Twenty users received celecoxib 200 mg once a day for five days and the other twenty users received the placebo in the same manner The participants were requested to maintain their daily record of bleeding, adverse effects, and satisfaction.
The percentage of the subjects whom bleeding was stopped within 7 days after initial treatment was significantly higher in the celecoxib group than in the placebo group (70% vs. 0%; p < 0.001). The mean duration of bleeding-free interval was significantly longer in celecoxib than placebo group (24.0 +/- 1.65 days vs. 10.0 +/- 6.50 days; p < 0.001). The mean duration of bleeding days was significantly shorter in celecoxib than placebo group (5.0 +/- 1.65 vs. 19.0 +/- 6.50 days; p < 0.001). Patients satisfaction in celecoxib group was significantly higher than the placebo group (80% vs. 30%; p < 0.001). There was no detectable adverse effect in both groups.
Celecoxib was more effective than placebo in the short-term control of irregular bleeding in Jadelle users. The mechanism of nonsteroidal anti-inflammatory drugs (NSAIDs) for the reduction of endometrial bleeding is likely from COX-2 inhibition.
评估塞来昔布和安慰剂对控制使用左炔诺孕酮宫内节育系统（Jadelle）的女性不规则子宫出血的疗效。
随机双盲安慰剂对照试验。
泰国曼谷朱拉隆功国王纪念医院计划生育诊所。
40名有不规则出血的Jadelle使用者被随机分为两组。20名使用者每天服用一次200毫克塞来昔布，共五天，另外20名使用者以相同方式服用安慰剂。参与者被要求记录每日出血情况、不良反应和满意度。
初始治疗后7天内出血停止的受试者百分比，塞来昔布组显著高于安慰剂组（70%对0%；p < 0.001）。塞来昔布组无出血间隔的平均持续时间显著长于安慰剂组（24.0 +/- 1.65天对10.0 +/- 6.50天；p < 0.001）。塞来昔布组的平均出血天数显著短于安慰剂组（5.0 +/- 1.65天对19.0 +/- 6.50天；p < 0.001）。塞来昔布组患者的满意度显著高于安慰剂组（80%对30%；p < 0.001）。两组均未检测到不良反应。
在短期控制Jadelle使用者的不规则出血方面，塞来昔布比安慰剂更有效。非甾体抗炎药（NSAIDs）减少子宫内膜出血的机制可能是通过抑制COX-2。
