Kim J W, Fletcher D L, Campion D R, Gaskins H R, Dean R
Department of Poultry Science, University of Georgia, Athens 30602.
Biochem Biophys Res Commun. 1991 Oct 15;180(1):1-7. doi: 10.1016/s0006-291x(05)81246-x.
The effects of dietary restriction on the relative steady state levels of cellular myc (c-myc) mRNA in abdominal adipose tissue, breast muscle and liver of chickens were determined. Fasting was found to increase c-myc RNA expression in adipose tissue (p less than 0.01). This increase returned to normal levels after refeeding. Muscle and liver in fasted birds did not show changes in c-myc that differed from controls. Serum concentrations of glucose, triglyceride (TG), free fatty acids (FFA) and insulin-like growth factor (IGF-I) were compared to levels of c-myc found in control birds. In adipose tissue, c-myc levels were negatively correlated with serum glucose, TG and IGF-I, while in muscle a positive correlation with serum glucose and TG was found. Data suggest that c-myc is involved in the metabolic changes occurring in fat cells under fasting conditions.
研究了饮食限制对鸡腹部脂肪组织、胸肌和肝脏中细胞myc（c-myc）mRNA相对稳态水平的影响。结果发现，禁食会增加脂肪组织中c-myc RNA的表达（p<0.01）。再喂食后，这种增加恢复到正常水平。禁食鸡的肌肉和肝脏中c-myc没有显示出与对照组不同的变化。将葡萄糖、甘油三酯（TG）、游离脂肪酸（FFA）和胰岛素样生长因子（IGF-I）的血清浓度与对照鸡中发现的c-myc水平进行了比较。在脂肪组织中，c-myc水平与血清葡萄糖、TG和IGF-I呈负相关，而在肌肉中，与血清葡萄糖和TG呈正相关。数据表明，c-myc参与了禁食条件下脂肪细胞发生的代谢变化。
